Dermatology Online Journal 11 (2): 8 2005

副作用：flushing (up to 10 %), Peripheral ankle or pedal edema (up to 30 %) gingival hyperplasia (up to 21 %)、 facial or truncal telangiectasia, photosensitivity reactions, new-onset psoriasis (as well as exacerbation of it), purpuric exanthems, pemphigoid manifestations, subacute cutaneous lupus erythematosus, gynecomastia, erythromelalgia, oral ulcers

用途：Raynaud phenomenon、chilblains (perniosis). chronic anal fissures, keloids, burn scars, idiopathic or CREST-related calcinosis cutis (calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, telangiectasias), prevention and treatment of skin flap necrosis